If you are eligible and decide to take part in the TRANSCEND-T2D-2 Study, you will be randomly assigned to 1 of 3 groups. Two of these groups will take the investigational medicine. The remaining group will take a marketed product that has been approved for the treatment of type 2 diabetes. Each of the 2 groups taking the investigational medicine will be assigned a different dose.
You will take your study medicine as an injection once weekly for 80–104 weeks. During the study, you will attend in-person visits with doctors and researchers at the study center.
All participants will receive close health monitoring by the research team of specialized healthcare professionals.
1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424456/
2 https://s3-eu-west-1.amazonaws.com/wof-files/World_Obesity_Atlas_2023_Report.pdf
3 https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
4 https://www.heart.org/en/health-topics/heart-failure/what-is-heart-failure
5 https://www.cdc.gov/heart-disease/risk-factors/index.html
6 https://www.nhlbi.nih.gov/health/sleep-apnea
7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561280/
8 https://pubmed.ncbi.nlm.nih.gov/37202064/
9 https://www.cdc.gov/arthritis/types/osteoarthritis.htm
10 https://onlinelibrary.wiley.com/doi/10.1002/art.42089
12 https://www.who.int/news-room/fact-sheets/detail/diabetes
1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424456/
2 https://s3-eu-west-1.amazonaws.com/wof-files/World_Obesity_Atlas_2023_Report.pdf
3 https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
4 https://www.heart.org/en/health-topics/heart-failure/what-is-heart-failure
5 https://www.cdc.gov/heart-disease/risk-factors/index.html
6 https://www.nhlbi.nih.gov/health/sleep-apnea
7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561280/
8 https://pubmed.ncbi.nlm.nih.gov/37202064/
9 https://www.cdc.gov/arthritis/types/osteoarthritis.htm
10 https://onlinelibrary.wiley.com/doi/10.1002/art.42089
12 https://www.who.int/news-room/fact-sheets/detail/diabetes
1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424456/
2 https://s3-eu-west-1.amazonaws.com/wof-files/World_Obesity_Atlas_2023_Report.pdf
3 https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
4 https://www.heart.org/en/health-topics/heart-failure/what-is-heart-failure
5 https://www.cdc.gov/heart-disease/risk-factors/index.html
6 https://www.nhlbi.nih.gov/health/sleep-apnea
7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561280/
8 https://pubmed.ncbi.nlm.nih.gov/37202064/
9 https://www.cdc.gov/arthritis/types/osteoarthritis.htm
10 https://onlinelibrary.wiley.com/doi/10.1002/art.42089
12 https://www.who.int/news-room/fact-sheets/detail/diabetes
1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424456/
2 https://s3-eu-west-1.amazonaws.com/wof-files/World_Obesity_Atlas_2023_Report.pdf
3 https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
4 https://www.heart.org/en/health-topics/heart-failure/what-is-heart-failure
5 https://www.cdc.gov/heart-disease/risk-factors/index.html
6 https://www.nhlbi.nih.gov/health/sleep-apnea
7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561280/
8 https://pubmed.ncbi.nlm.nih.gov/37202064/
9 https://www.cdc.gov/arthritis/types/osteoarthritis.htm
10 https://onlinelibrary.wiley.com/doi/10.1002/art.42089
12 https://www.who.int/news-room/fact-sheets/detail/diabetes
1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424456/
2 https://s3-eu-west-1.amazonaws.com/wof-files/World_Obesity_Atlas_2023_Report.pdf
3 https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
4 https://www.heart.org/en/health-topics/heart-failure/what-is-heart-failure
5 https://www.cdc.gov/heart-disease/risk-factors/index.html
6 https://www.nhlbi.nih.gov/health/sleep-apnea
7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561280/
8 https://pubmed.ncbi.nlm.nih.gov/37202064/
9 https://www.cdc.gov/arthritis/types/osteoarthritis.htm
10 https://onlinelibrary.wiley.com/doi/10.1002/art.42089
12 https://www.who.int/news-room/fact-sheets/detail/diabetes
1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424456/
2 https://s3-eu-west-1.amazonaws.com/wof-files/World_Obesity_Atlas_2023_Report.pdf
3 https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
4 https://www.heart.org/en/health-topics/heart-failure/what-is-heart-failure
5 https://www.cdc.gov/heart-disease/risk-factors/index.html
6 https://www.nhlbi.nih.gov/health/sleep-apnea
7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561280/
8 https://pubmed.ncbi.nlm.nih.gov/37202064/
9 https://www.cdc.gov/arthritis/types/osteoarthritis.htm
10 https://onlinelibrary.wiley.com/doi/10.1002/art.42089
12 https://www.who.int/news-room/fact-sheets/detail/diabetes
1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424456/
2 https://s3-eu-west-1.amazonaws.com/wof-files/World_Obesity_Atlas_2023_Report.pdf
3 https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
4 https://www.heart.org/en/health-topics/heart-failure/what-is-heart-failure
5 https://www.cdc.gov/heart-disease/risk-factors/index.html
6 https://www.nhlbi.nih.gov/health/sleep-apnea
7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561280/
8 https://pubmed.ncbi.nlm.nih.gov/37202064/
9 https://www.cdc.gov/arthritis/types/osteoarthritis.htm
10 https://onlinelibrary.wiley.com/doi/10.1002/art.42089
12 https://www.who.int/news-room/fact-sheets/detail/diabetes
1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424456/
2 https://s3-eu-west-1.amazonaws.com/wof-files/World_Obesity_Atlas_2023_Report.pdf
3 https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
4 https://www.heart.org/en/health-topics/heart-failure/what-is-heart-failure
5 https://www.cdc.gov/heart-disease/risk-factors/index.html
6 https://www.nhlbi.nih.gov/health/sleep-apnea
7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561280/
8 https://pubmed.ncbi.nlm.nih.gov/37202064/
9 https://www.cdc.gov/arthritis/types/osteoarthritis.htm
10 https://onlinelibrary.wiley.com/doi/10.1002/art.42089
12 https://www.who.int/news-room/fact-sheets/detail/diabetes
1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424456/
2 https://s3-eu-west-1.amazonaws.com/wof-files/World_Obesity_Atlas_2023_Report.pdf
3 https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
4 https://www.heart.org/en/health-topics/heart-failure/what-is-heart-failure
5 https://www.cdc.gov/heart-disease/risk-factors/index.html
6 https://www.nhlbi.nih.gov/health/sleep-apnea
7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561280/
8 https://pubmed.ncbi.nlm.nih.gov/37202064/
9 https://www.cdc.gov/arthritis/types/osteoarthritis.htm
10 https://onlinelibrary.wiley.com/doi/10.1002/art.42089
12 https://www.who.int/news-room/fact-sheets/detail/diabetes
1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424456/
2 https://s3-eu-west-1.amazonaws.com/wof-files/World_Obesity_Atlas_2023_Report.pdf
3 https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
4 https://www.heart.org/en/health-topics/heart-failure/what-is-heart-failure
5 https://www.cdc.gov/heart-disease/risk-factors/index.html
6 https://www.nhlbi.nih.gov/health/sleep-apnea
7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561280/
8 https://pubmed.ncbi.nlm.nih.gov/37202064/
9 https://www.cdc.gov/arthritis/types/osteoarthritis.htm
10 https://onlinelibrary.wiley.com/doi/10.1002/art.42089
12 https://www.who.int/news-room/fact-sheets/detail/diabetes
1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424456/
2 https://s3-eu-west-1.amazonaws.com/wof-files/World_Obesity_Atlas_2023_Report.pdf
3 https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
4 https://www.heart.org/en/health-topics/heart-failure/what-is-heart-failure
5 https://www.cdc.gov/heart-disease/risk-factors/index.html
6 https://www.nhlbi.nih.gov/health/sleep-apnea
7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561280/
8 https://pubmed.ncbi.nlm.nih.gov/37202064/
9 https://www.cdc.gov/arthritis/types/osteoarthritis.htm
10 https://onlinelibrary.wiley.com/doi/10.1002/art.42089
12 https://www.who.int/news-room/fact-sheets/detail/diabetes
1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424456/
2 https://s3-eu-west-1.amazonaws.com/wof-files/World_Obesity_Atlas_2023_Report.pdf
3 https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
4 https://www.heart.org/en/health-topics/heart-failure/what-is-heart-failure
5 https://www.cdc.gov/heart-disease/risk-factors/index.html
6 https://www.nhlbi.nih.gov/health/sleep-apnea
7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561280/
8 https://pubmed.ncbi.nlm.nih.gov/37202064/
9 https://www.cdc.gov/arthritis/types/osteoarthritis.htm
10 https://onlinelibrary.wiley.com/doi/10.1002/art.42089
12 https://www.who.int/news-room/fact-sheets/detail/diabetes
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